Modafinil Study – MRI Scan Shows Modafinil Helps Attention

modafinil helps attention mriA new study carried out in April 2017 has shown that using Modafinil helps attention in healthy adults. This is not exactly news to anyone who has tried modafinil before – laser like focus and concentration is kind of what this stuff is renowned for. However, a good old double blind study to back up this anecdotal evidence is always great to read. Personally I imagine being strapped into an MRI scanner whilst on modafinil would be one seriously intense experience. Not sure how the participants could not know they had taken the actual drug and not the placebo.

Below is the abstract reproduced in full.

Modafinil Study Rationale

Modafinil is a wake-promoting agent and has been reported to be effective in improving attention in patients with attentional disturbance. However, neural substrates underlying the modafinil effects on attention are not fully understood.

Objectives

We employed a functional magnetic resonance imaging (fMRI) study with the attention network test (ANT) task in healthy adults and examined which networks of attention are mainly affected by modafinil and which neural substrates are responsible for the drug effects.

Methods

We used a randomized placebo-controlled within-subjects cross-over design. Twenty-three healthy adults participated in two series of an fMRI study, taking either a placebo or modafinil. The participants performed the ANT task, which is designed to measure three distinct attentional networks, alerting, orienting, and executive control, during the fMRI scanning. The effects of modafinil on behavioral performance and regional brain activity were analyzed.

Results

We found that modafinil enhanced alerting performance and showed greater alerting network activity in the left middle and inferior occipital gyri as compared with the placebo. The brain activations in the occipital regions were positively correlated with alerting performance.

Conclusions

Modafinil enhanced alerting performance and increased activation in the occipital lobe in the alerting network possibly relevant to noradrenergic activity during the ANT task. The present study may provide a rationale for the treatment of patients with distinct symptoms of impaired attention.

TL:DR – modafinil helps attention in healthy adults.

Abstract available here https://www.ncbi.nlm.nih.gov/pubmed/28374089

If you are looking for something to help your attention then check out our list of top rated suppliers to get your hands on some modafinil wherever you live in the world.